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A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease
Shikonin is a major component of a Chinese herbal medicine named zicao
11(10):738-46
PubMed Central PMCID: PMC4155816
CAS Number: 1092776-63-0
Fostriecin sodium salt Catalog No.:M22411-C A novel CMKLR1 small moleculeIC50: Inhibit protein phosphatase types 2A (PP2A) and 4 (PP4) intensively with an IC50 of 1. 5 nM and 3 nM respectively. Inhibit topoisomerase II (Topo II) and protein phosphatase type 1 (PP1) slightly with an IC50 of 40 M and 131 M respectively. Fostriecin, an anti tumor antibiotic originates from Streptomyces pulveraceus, is considered to exert its activity by interfering the reversible phosphorylation of several important proteins in cell cycle.
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