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6-24 hours) KRAS G12C degradation modulates Erk signaling in homozygous and heterozygous KRAS mutant cell lines
28)11(12)6-10/h10-13
SNAP 94847 (oral gavage
IPSU increases sleep when dosed during the mouse active phase (lights off)
HTI-286 hydrochloride
(3S, 5S)-Atorvastatin (sodium salt) yl-(3' 5')-guanosine 6-24 hours) KRAS G12C degradationAtorvastatin exists in four optical forms. The (3R, 5R) atorvastatin enantiomer displays the greatest activity against HMG CoA reductase. (3S,5S) Atorvastatin is an enantiomer of atorvastatin with little or no inhibitory activity against HMG CoA reductase . Atorvastatin is a synthetic HMG CoA reductase inhibitor implicated in lowering plasma cholesterol levels by inhibiting endogenous cholesterol synthesis. Atorvastatin also reduces triglyceride
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