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KP-MRT-RY (RY)
S3I-201 (NSC-74859) preferentially inhibits Stat3 DNA-binding activity over that of Stat1 (IC50 values
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination
potencies which may be expected for an ATP competitive inhibitor
including PTEN-deficient prostate cancer models LNCaP and PC3
TEPP-46 (ML265) - Pyruvate Kinase M2 (PKM2) Activator. CAS# 1221186-53-3 60123 KP-MRT-RY (RY)TEPP 46 (ML265), CAS No. 1221186 53 3, is a potent and selective Pyruvate kinase M2 (PKM2) activator with EC50 ~92 nM. It demonstrates >100 fold selectivity for PKM2 over the related PKM1, PKR, and PKL isoforms. It can stabilize pyruvate kinase subunit interactions, promote PKM2 tetramer formation and prevent inhibition by phosphotyrosine signaling. It can alter metabolism in cultured cells, and inhibit xenograft tumor growth in vivo. TEPP 46 inhibits
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