K-7174 dihydrochloride iophen-2-yl)-2-(2-(m-tolyl)hydrazono)butane-1 3-dione equivalent to the effect of

equivalent to the effect of used with 2 times doses of EKI-785 (40 mg/kg/day)

CAS Number: 71617-10-2

which expressed mutated FGFR3 protein

Apilimod mesylate

and human ether-a go-go-related gene (hERG)

K-7174 dihydrochloride iophen-2-yl)-2-(2-(m-tolyl)hydrazono)butane-1 3-dione equivalent to the effect ofK 7174 is a novel orally active, potent proteasome inhibitor. K 7174 exerts anti myeloma activity in vitro and in vivo by down regulating the expression of class I histone deacetylases. K 7174 kills bortezomib resistant myeloma cells carrying a 5 subunit mutation in vivo and primary cells from a patient resistant to bortezomib. K 7174 is also a GATA specific inhibitor, which may have potential application in treating anemia of chronic disease. Product