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VU0467485 (1-10 mg/kg
it inhibits the epithelial sodium channel (ENaC) with an IC50 of 400 nM (Amiloride=776 nM)
InChi: InChI=1S/C13H13FN2O2S
Na/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2
GSK1838705A also inhibits the anaplastic lymphoma kinase (ALK)
PF-06305591 206Cyclodextrin VU0467485 (1-10 mg/kgPF 06305591 is a potent and highly selective voltage gated sodium channel NaV1. 8 blocker, with an IC50 of 15 nM. An excellent preclinical in vitro ADME and safety profile. Product information CAS Number: 1449473 97 5 Molecular Weight: 274. 36 Formula: C15H22N4O Chemical Name: (2R,3S) 3 amino 3 (5 tert butyl 1H 1,3 benzodiazol 2 yl) 2 methylpropanamide Smiles: C[C@H]([C@H](N)C1NC2=CC=C(C=C2N=1)C(C)(C)C)C(N)=O InChiKey: APWZIFIAVVFPNT PELKAZGASA N