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proteasome-independent mechanism that influences remodelling of the cytoskeleton
SAR407899 (1
Formula: C18H16NNaO5
19-Oxocinobufagin is a bufadienolide in toad venom
2'-piperidin]-18-eneoxy]-5-{[(2S
R1498 do-tri-(carboxyethoxymethyl)-methane proteasome-independent mechanism that influences remodellingR1498 is a multi target kinase inhibitor with anti angiogenic and anti proliferative activities. R1498 mainly targets targets such as Aurora kinase and VEGFR2, which are associated with tumor development. R1498 showed moderate in vitro growth inhibition in a variety of tumor cells, with IC50 values in the micromolar range. R1498 showed anti tumor efficacy superior to sorafenib in a variety of gastric cancer and hepatocellular carcinoma xenograft
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