LLY-507 - Protein-lysine Methyltransferase SMYD2 Inhibitor. CAS# 1793053-37-8 Asn-PAB-PNP Smiles: CS(=O)(=O)N(CC(O)CN1C2=CC=CC=C2C2=CC=CC=C12)CC1=CC=CO1

Smiles: CS(=O)(=O)N(CC(O)CN1C2=CC=CC=C2C2=CC=CC=C12)CC1=CC=CO1

Chemical Name: N

(2016) Nature

It is inactive to PKCμ

the genes coding for isocitrate dehydrogenases 1 and 2

LLY-507 - Protein-lysine Methyltransferase SMYD2 Inhibitor. CAS# 1793053-37-8 Asn-PAB-PNP Smiles: CS(=O)(=O)N(CC(O)CN1C2=CC=CC=C2C2=CC=CC=C12)CC1=CC=CO1LLY 507, CAS No. 1793053 37 8, is a potent, selective and cell permeable protein lysine methyltransferase SMYD2 inhibitor with IC50 <15 nM. It binds in the substrate peptide binding pocket. It has >100 fold selectivity over other methyltransferases and other non epigenetic targets. LLY 507 has been shown to inhibit p53K370 monomethylation in cells with an IC50 ~600 nM. It inhibited the proliferation of several esophageal, liver, and breast cancer cell