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P-glycoprotein (ABCB1/MDR1) limits brain accumulation and Cytochrome P450-3A (CYP3A) restricts oral availability of the novel FGFR4 inhibitor fisogatinib (BLU-554)
27-24+/t28-
InChi: InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H
It has been shown to produce sedative and anorectic effects in animals
InChiKey: JNLSTLQFDDAULK-UHFFFAOYSA-N
CGS 19755 Catalog No.:M23351-C P-glycoprotein (ABCB1/MDR1) limits brain accumulationProduct information CAS Number: 110347 85 8 Molecular Weight: 223. 16 Formula: C7H14NO5P Chemical Name: (2S,4R) 4 (phosphonomethyl)piperidine 2 carboxylic acid Smiles: OC(=O)[C@@H]1C[C@H](CP(O)(O)=O)CCN1 InChiKey: LPMRCCNDNGONCD RITPCOANSA N InChi: InChI=1S C7H14NO5P c9 7(10)6 3 5(1 2 8 6)4 14(11,12)13 h5 6,8H,1 4H2,(H,9,10)(H2,11,12,13) t5 ,6+ m1 s1 Technical Data Appearance: Solid Power Purity: 98% (or refer to the Certificate of Analysis) Shipping