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Pyridone 6 interferes with JAK kinase activity by interacting within the ATP-binding cleft
a furocoumarin naturally occurring tricyclic aromatic compound
Chemical Name: (R)-3-(4-(7H-pyrrolo[2
InChi: InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15
17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-11
K-Ras ligand-Linker Conjugate 4 Catalog No.:M14597-2 Pyridone 6 interferes with JAKK Ras ligand Linker Conjugate 4 incorporates a ligand for K Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K Ras ligand Linker Conjugate 4 can be used in the synthesis of PROTAC K Ras Degrader 1 (HY 129523), which is potent PROTAC K Ras degrader that exhibits 70% degradation efficacy in SW1573 cells. Product information CAS Number: 2378261 83 5 Molecular Weight: 697. 82 Formula: C35H51N7O8
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