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PubMed Central PMCID: PMC3632326
GSK 2256098
Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration-dependent modulation of multiple nuclear receptor-mediated pathways in androgen-responsive prostate cancer cell LNCaP
Chemical Name: (2E)-1-(6
Naunyn Schmiedebergs Arch Pharmacol
BMH-21 - CAS# 896705-16-1 Catalog No.:M7093-2 PubMed Central PMCID: PMC3632326BMH 21, CAS No. 896705 16 1, is a potent small molecule DNA intercalator. BMH 21 binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. BMH 21 does not cause phosphorylation of H2AX, a key biomarker activated in DNA damage stress. BMH 21 effects on the nucleolar stress response were independent of major DNA damage associated PI3 kinase pathways, ATM, ATR and DNA PKcs. BMH 21 is a chemically unique DNA intercalator that has high
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