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exhibits moderate clearance and good oral bioavailability in multiple animal models
Pitstop-induced inhibition of clathrin TD function acutely interferes with receptor-mediated endocytosis
InChi: InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22
31)32)20-5-3-2-4-6-20/h2-10
Formula: C29H27F5N6O4
LU-32-176B Y (human) exhibits moderate clearance and goodLU 32 176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU 32 176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2M, 1M, 4M, respectively. Product information CAS Number: 770688 66 9 Molecular Weight: 398. 45 Formula: C23H24F2N2O2 Chemical Name: 4 {[4,4 bis(4 fluorophenyl)butyl]amino} 2,3,4,5,6,7 hexahydro 1,2 benzoxazol 3 one Smiles:
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