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293(19):7476-7485
Aconiazide is an anti-tuberculosis prodrug
CAS Number: 3326-34-9
Smiles: CN(CCCOC1C=CC(=CC=1)S(=O)(=O)C1=C(C(C)C)N(C)C2=CC=CC=C21)CCC1=CC(OC)=C(C=C1)OC
cytoplasmic histone-associated-DNA-fragments
Necrostatin-1 Size:Solid 2 mg 293(19):7476-7485Necrostatin 1 is a potent and selective inhibitor of necroptosis, a mechanism of programmed cell death separate from apoptosis. Necrostatin 1 functions as an allosteric inhibitor of the death domain receptor associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin 1 does not present any perturbation of the Fas TNFR triggered canonical apoptosis cascade. Necrostatin 1 inhibits RIP1